Brisbane have marked Ally Anderson's milestone and Kate Lutkins' comeback with a 44-point AFLW belting of Essendon.

The Lions dominated from the start on Sunday at Burpengary and goalkicking inaccuracy was their only flaw in a 8.14 (62) to 3.0 (18) win.

Anderson had 23 possessions, becoming the sixth AFLW player and the first Indigenous woman to rack up 1000 career disposals.

Lutkins took less than nine months to return from the ACL rupture she suffered on January 9, making a successful comeback in defence.

"That's a huge achievement for Ally. The fact she's the first Indigenous player to do that highlights it even more," Lions coach Craig Starcevich said.

He added Lutkins, one of the AFLW's top players, had been as excited as a first-gamer all week.

"She knows she's pushing the envelope a little bit in terms of the timeframe of a normal ACL," he said.

"But the more the weeks go by and the more we survive games like today, and the fact she was able to get out there and make an impact ... was really nice to see."

The win was important for the Lions, given they were coming off last week's upset loss to Richmond - their first for the season.

"It was good to see some reward for effort and get back to where we need to be playing," Starcevich said.

"It was good to get our habits back and the way we want to play."

Apart from Anderson, Emily Bates was solid in the midfield and Tahlia Hickie impressed in the ruck.

Jesse Wardlaw kicked 2.3, taking the Brisbane key forward to 11 goals for the season.

She shares the league goalkicking lead with St Kilda star Kate Shierlaw.

The Bombers did not kick their first score until 13 minutes into the third term and only managed two inside-50s to halftime.

It was the expansion team's biggest loss, but it could have been much worse - Brisbane hit the post four times in the first half and five for the match.

The Lions' physical pressure was also first-class, highlighted by a brutal tackle from Zimmie Farquarhson in the second term.

Essendon rallied in the second half, with Jo Doonan kicking their first goal from a free kick in the third term and Maddy Prespakis quickly adding their second.

Prespakis again impressed for the Bombers, racking up 20 possessions and nine tackles, but her team was given a reality check by the Lions.

Brisbane had 32 clearances to 15 and dominated inside-50s 45-13, although Essendon won the tackle count 58-56.

"They're premiership favourites, or up there at least, and I guess we got a first-hand view today as to why," Bombers coach Natalie Wood said.